|
KMID : 0363320180390010009
|
|
Journal of Korean Oriental Internal Medicine
2018 Volume.39 No. 1 p.9 ~ p.21
|
|
|
The Clinical Study of Ahnjeonbaekho-tang on Patients with Graves’ Disease
|
|
Lee Byung-Cheol
Han Yang-Hee
Shin Seon-Mi
Ahn Se-Young
Cho Chung-Sik
|
|
|
Abstract
|
|
|
Objective: Graves' disease, the most common cause of primary hyperthyroidism, is a thyroid specific autoimmune disorder. When resistance to medication is shown in spite of long term therapy with anti-thyroid drugs, radioactive iodine therapy would be chosen in Western medicine. However, this therapy has often been reported to cause patients have hypothyroidism, thus requiring them to take levothyroxine for the rest of their lives. In this study, we evaluate the clinical efficacy and safety of Ahnjeonbaekho-tang (AJBHT) on patients with Graves’ disease.
Methods: We prescribed AJBHT for 3 months to two groups: patients who had been taking antithyroid drugs were administered AJBHT after discontinuing the antithyroid drugs (Com-Tx→Single-Tx), and patients who had not been taking antithyroid drugs were started with AJBHT (Single-Tx) immediately. We evaluated the thyroidal function test (TFT) and visual analogue scale (VAS) for clinical symptoms for 3 months.
Results: Serum T3 and fT4 were significantly decreased in both groups and remission rate of thyroidal hormones were significantly improved in the Single-Tx group. The clinical symptoms of palpitation, fatigue, and heat intolerance were significantly improved in both groups. In the safety analysis, all patients were in normal range of liver, renal function blood test and common blood count.
Conclusion: From these results, we suggested that AJBHT was effective on TFT and clinical symptoms of Graves’ disease. The study supports that AJBHT may be a useful agent for patients with Graves’ disease who are resistant to antithyroid medication or radioactive iodine therapy, and for patients at first diagnosis.
|
|
|
KEYWORD
|
|
|
Graves' disease, thyroid function test, visual analogue scale, antithyroid drug, Ahnjeonbaekho-tang
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|